DeNovo® NT Natural Tissue Graft

DeNovoNT Natural Tissue Graft is a juvenile cartilage allograft tissue intended to provide surgeons with an early-intervention option for the repair of articular cartilage in a wide range of anatomic focal cartilage defects.  It offers a single-stage procedure with fibrin fixation that eliminates the need for harvesting a periosteal flap. 

Juvenile Cartilage Tissue

DeNovoNT Graft consists of particulated natural articular cartilage with living cells.  The tissues are recovered from juvenile donor joints.

Single-Stage Procedure with Fibrin Adhesive

  • Simplified surgical technique
  • No need to harvest and sew a periosteal flap
  • No donor site morbidity

Pre-Clinical Evidence*

Demonstrated in Equine Trochlea Model at 6 Months Post-implanation1 :

  • Defect filling with a continuous volume of cartilage repair tissue after implanation of particulated cartilage tissue pieces.
  • Minimal subchondral bone resorption; and
  • No indication of tissue rejection/inflammation.

Clinical Experience

  • Human clinical experience to date includes greater than 2.5 years of implant history
  • DeNovoNT Graft has been used to treat focal articular defects in a wide range of anatomical applications (knee, ankle, hip, shoulder, elbow, great toe)

* Animal Study results are not necessarily predictive of human results.

Reference:

  1. Frisbie et al. Data on file at ISTO Technologies, Inc.